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Some of you may be interested in this update on Long COVID from
epidemiologist Katelyn Jetelina. I thought I was following this
topic pretty well, but there's some new info here that was
surprising to me.--Manny<br>
<br>
<pre class="moz-signature" cols="72">"Fight for the things that you care about, but do it
in a way that will lead others to join you."
― Ruth Bader Ginsburg </pre>
<div class="moz-forward-container"><br>
<br>
-------- Forwarded Message --------
<table class="moz-email-headers-table" cellspacing="0"
cellpadding="0" border="0">
<tbody>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Subject:
</th>
<td>Catch up quick: Long COVID</td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Date:
</th>
<td>Tue, 14 Mar 2023 16:16:26 +0000</td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">From:
</th>
<td>Katelyn Jetelina from Your Local Epidemiologist <a
class="moz-txt-link-rfc2396E"
href="mailto:yourlocalepidemiologist@substack.com"
moz-do-not-send="true"><yourlocalepidemiologist@substack.com></a></td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Reply-To:
</th>
<td>Katelyn Jetelina from Your Local Epidemiologist
<a class="moz-txt-link-rfc2396E"
href="mailto:reply+1rzqc6&a13t&&32b2ca6b5635e96470cad40341181835d29b5f2c82e9746ff82b488c42922e2f@mg1.substack.com"
moz-do-not-send="true"><reply+1rzqc6&a13t&&32b2ca6b5635e96470cad40341181835d29b5f2c82e9746ff82b488c42922e2f@mg1.substack.com></a></td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">To: </th>
<td><a class="moz-txt-link-abbreviated"
href="mailto:manny@ratafias.com"
moz-do-not-send="true">manny@ratafias.com</a></td>
</tr>
</tbody>
</table>
<br>
<br>
<title>Catch up quick: Long COVID</title>
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src="https://mailgun.substack.com/api/v1/email/open?token=eyJtIjoiPDIwMjMwMzE0MTYxNjI2LjMuODUyZjRhOGQ2NWQ4M2Y4MUBtZzIuc3Vic3RhY2suY29tPiIsInUiOjQ2Nzk5MywiciI6Im1hbm55QHJhdGFmaWFzLmNvbSIsImQiOiJtZzIuc3Vic3RhY2suY29tIiwicCI6MTA3NDgyOTAyLCJ0IjoibmV3c2xldHRlciIsImEiOiJldmVyeW9uZSIsInMiOjI4MTIxOSwiYyI6InBvc3QiLCJmIjp0cnVlLCJwb3NpdGlvbiI6InRvcCIsImlhdCI6MTY3ODgxMDYwOSwiZXhwIjoxNjgxNDAyNjA5LCJpc3MiOiJwdWItMCIsInN1YiI6ImVvIn0.RBDy69iHQGTPPyPfVE2u6NHZofigAamylTWN23HnFMY"
alt="" style="height:1px !important;width:1px
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!important;padding-bottom:0 !important;padding-right:0
!important;padding-left:0 !important;" moz-do-not-send="true"
width="1" height="1" border="0">
<div
style="display:none;font-size:1px;color:#333333;line-height:1px;max-height:0px;max-width:0px;opacity:0;overflow:hidden;"
class="preview">COVID-19 is not the common cold. Here’s an
effort to keep you up-to-date on long COVID developments. Not
“in the clear” after first infection What we knew: Long COVID
after first infection was clearly a risk. The risk of long
COVID-19 after re-infection
</div>
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width="100%" cellspacing="0" cellpadding="0" border="0">
<tbody>
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<td><br>
</td>
<td class="content" width="550"><br>
</td>
<td><br>
</td>
</tr>
<tr>
<td><br>
</td>
<td class="content" width="550" align="left">
<div style="font-size: 16px; line-height: 26px; margin:
0 auto; max-width: 550px; overflow-wrap: break-word;
width: 100%;">
<table role="presentation" width="100%"
cellspacing="0" cellpadding="0" border="0">
<tbody>
<tr>
<td style="height: 20px;" align="right">
<table role="presentation" width="auto"
cellspacing="0" cellpadding="0" border="0">
<tbody>
<tr>
<td style="vertical-align: middle;"><span
class="tw-font-body tw-text-ssm
tw-text-substack-secondary"
style="color: #808080 !important;
font-family: SF Pro Text,
-apple-system, BlinkMacSystemFont,
Inter, Segoe UI, Roboto, Helvetica,
Arial, sans-serif, Apple Color
Emoji, Segoe UI Emoji, Segoe UI
Symbol !important; font-size: 13px
!important;"><a
href="https://open.substack.com/pub/yourlocalepidemiologist/p/catch-up-quick-long-covid?utm_source=email&redirect=app-store"
class="tw-text-substack-secondary
tw-underline"
style="-webkit-text-decoration-line:
underline !important; color:
#808080 !important;
text-decoration-line: underline
!important;"
moz-do-not-send="true">Open in app</a>
or <a
href="https://substack.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.s3DGz_Cd3PR4jYfL1w3L9uLAZP7DpMbgkeCNpDGct8Y?"
class="tw-text-substack-secondary
tw-underline"
style="-webkit-text-decoration-line:
underline !important; color:
#808080 !important;
text-decoration-line: underline
!important;"
moz-do-not-send="true">online</a></span></td>
</tr>
</tbody>
</table>
</td>
</tr>
</tbody>
</table>
<table role="presentation" class="header
graphic-header" style="border-spacing: 0; padding:
16px 0 32px;" width="auto">
<tbody>
<tr>
<td style="padding: 0; text-align: center;"
align="center"><a
href="https://substack.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.s3DGz_Cd3PR4jYfL1w3L9uLAZP7DpMbgkeCNpDGct8Y?"
moz-do-not-send="true"><img
role="presentation"
src="https://substackcdn.com/image/fetch/w_1100,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F523ac601-a63a-4d07-906e-bc4e7bfbb83a_2200x440.png"
class="header-image" style="border: none
!important; display: block; height: auto;
margin: 0 auto; max-width: 550px;
vertical-align: middle; width: 100%;"
moz-do-not-send="true" width="550"
height="110"></a></td>
</tr>
</tbody>
</table>
<div class="typography" style="font-size: 16px;
line-height: 26px;">
<div class="preamble" style="font-size: 16px;
line-height: 26px; margin-top: 16px;">
<div dir="auto" class="body markup"
style="font-size: 16px; line-height: 26px;
margin-bottom: 16px; text-align: initial; width:
100%; word-break: break-word;">
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;
margin-bottom: 0; margin-top: 0;"><em><span>Si
quiere leer la versión en español, pulse </span><a
href="https://substack.com/redirect/862304a6-192f-4bfb-99b7-2537368996b9?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">aquí</a><span>.</span></em></p>
</div>
<hr style="background: #e0e0e0; border: none;
height: 1px; margin: 16px 0 0; padding: 0;"></div>
</div>
<div dir="auto" class="post typography"
style="font-size: 16px; line-height: 26px; padding:
16px 0 0 0;">
<div class="post-header" style="font-size: 16px;
line-height: 26px;">
<h1 class="post-title published"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Pro Display', -apple-system,
BlinkMacSystemFont, 'Inter', 'Segoe UI', Roboto,
Helvetica, Arial, sans-serif, 'Apple Color
Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';
font-size: 32px; font-weight: 900; line-height:
36px; margin: 0;"><a
href="https://substack.com/app-link/post?publication_id=281219&post_id=107482902&utm_source=post-email-title&isFreemail=true&token=eyJ1c2VyX2lkIjo0Njc5OTMsInBvc3RfaWQiOjEwNzQ4MjkwMiwiaWF0IjoxNjc4ODEwNjA4LCJleHAiOjE2ODE0MDI2MDgsImlzcyI6InB1Yi0yODEyMTkiLCJzdWIiOiJwb3N0LXJlYWN0aW9uIn0.lzHF-9mnF3mAaINnhWx2SRCr54tsPV_X1tMBWmmyV0Y"
style="color: #404040; text-decoration: none;"
moz-do-not-send="true">Catch up quick: Long
COVID</a></h1>
<table role="presentation" class="post-meta"
style="align-items: center; height: 20px;
margin: 1em 0;" width="100%" cellspacing="0"
cellpadding="0" border="0">
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<td>
<table role="presentation" width="auto"
cellspacing="0" cellpadding="0"
border="0">
<tbody>
<tr>
<td>
<table role="presentation"
width="auto" cellspacing="0"
cellpadding="0" border="0">
<tbody>
<tr>
<td style="vertical-align:
middle;">
<div
class="frontend-pencraft-Text-module__reset--20JLV
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custom-css-email-post-author" style="color: #404040; font-family: 'SF
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12px; font-weight: 500;
letter-spacing: 0.2px;
line-height: 20px;
margin: 0;
text-decoration: unset;
text-transform:
uppercase;"><a
href="https://substack.com/redirect/4df60a92-1a38-40fc-9d2b-703140fc9a50?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
style="color: #404040;
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'Segoe UI Symbol';
font-size: 12px;
font-weight: 500;
letter-spacing: 0.2px;
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margin: 0;
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uppercase;"
class="frontend-pencraft-Text-module__reset--20JLV
frontend-pencraft-Text-module__size-12--2onFT
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frontend-pencraft-Text-module__weight-medium--aTbx5
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frontend-pencraft-Text-module__color-primary--2I-sF
frontend-pencraft-Text-module__meta--3RRSj"
moz-do-not-send="true">Katelyn
Jetelina</a></div>
</td>
</tr>
</tbody>
</table>
</td>
</tr>
<tr>
<td>
<table role="presentation"
width="auto" cellspacing="0"
cellpadding="0" border="0">
<tbody>
<tr>
<td style="vertical-align:
middle;">
<div
class="frontend-pencraft-Text-module__reset--20JLV
frontend-pencraft-Text-module__size-12--2onFT
frontend-pencraft-Text-module__line-height-20--1soeQ
frontend-pencraft-Text-module__weight-medium--aTbx5
frontend-pencraft-Text-module__font-meta--2i-cR
frontend-pencraft-Text-module__color-secondary--XjVGl
frontend-pencraft-Text-module__meta--3RRSj"
style="color: #808080;
font-family: 'SF Compact
Text', 'SF Pro Text',
-apple-system,
BlinkMacSystemFont,
'Inter', 'Segoe UI',
Roboto, Helvetica,
Arial, sans-serif,
'Apple Color Emoji',
'Segoe UI Emoji', 'Segoe
UI Symbol'; font-size:
12px; font-weight: 500;
letter-spacing: 0.2px;
line-height: 20px;
margin: 0;
text-decoration: unset;
text-transform:
uppercase;"><time
datetime="2023-03-14T16:16:29.752Z">Mar
14</time></div>
</td>
</tr>
</tbody>
</table>
</td>
</tr>
</tbody>
</table>
</td>
<td align="right">
<table role="presentation" width="auto"
cellspacing="0" cellpadding="0"
border="0">
<tbody>
<tr>
<td style="vertical-align: middle;"><a
href="https://substack.com/redirect/4df60a92-1a38-40fc-9d2b-703140fc9a50?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
moz-do-not-send="true"><img
src="https://substackcdn.com/image/fetch/f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb1cf8441-2181-452a-a5af-364eb49b32b5_828x1792.png"
style="border: none
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<tbody>
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<td style="font-size: 0px; line-height: 0;"
height="16"> </td>
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cellspacing="0" cellpadding="0"
border="0">
<tbody>
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cellpadding="0" border="0">
<tbody>
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<table role="presentation"
width="38"
cellspacing="0"
cellpadding="0"
border="0">
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<td align="center"><a
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class="email-icon-button"
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alt=""
class="icon"
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</tbody>
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</td>
<td style="min-width: 8px"
width="8"><br>
</td>
<td style="vertical-align:
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<table role="presentation"
width="38"
cellspacing="0"
cellpadding="0"
border="0">
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<td align="center"><a
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class="email-icon-button"
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alt=""
class="icon"
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</tbody>
</table>
</td>
<td style="min-width: 8px"
width="8"><br>
</td>
<td style="vertical-align:
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<table role="presentation"
width="38"
cellspacing="0"
cellpadding="0"
border="0">
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class="email-icon-button"
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uppercase;"
moz-do-not-send="true"><span
class="email-button-text" style="vertical-align: middle;">Save</span></a></td>
</tr>
</tbody>
</table>
</td>
<td style="min-width: 8px"
width="8"><br>
</td>
<td style="vertical-align:
middle;">
<table role="presentation"
width="auto"
cellspacing="0"
cellpadding="0"
border="0">
<tbody>
<tr>
<td align="center"><a
href="https://open.substack.com/pub/yourlocalepidemiologist/p/catch-up-quick-long-covid?utm_source=email-ufi&play_audio=true&token=eyJ1c2VyX2lkIjo0Njc5OTMsInBvc3RfaWQiOjEwNzQ4MjkwMiwiaWF0IjoxNjc4ODEwNjA4LCJleHAiOjE2ODE0MDI2MDgsImlzcyI6InB1Yi0yODEyMTkiLCJzdWIiOiJwb3N0LXJlYWN0aW9uIn0.lzHF-9mnF3mAaINnhWx2SRCr54tsPV_X1tMBWmmyV0Y"
class="email-button-outline" style="border: 1px solid #e0e0e0;
border-radius:
100000px; color:
#808080;
display:
inline-block;
font-family: 'SF
Pro Text',
-apple-system,
ui-sans-serif,
BlinkMacSystemFont,
'Segoe UI',
Roboto,
Helvetica,
Arial,
sans-serif,
'Apple Color
Emoji', 'Segoe
UI Emoji',
'Segoe UI
Symbol';
font-size: 12px;
font-weight:
500;
line-height:
12px; padding:
9px 14px;
text-decoration:
none;
text-transform:
uppercase;"
moz-do-not-send="true"><span
class="email-button-text" style="vertical-align: middle;">▷ Listen</span></a></td>
</tr>
</tbody>
</table>
</td>
</tr>
</tbody>
</table>
</td>
</tr>
</tbody>
</table>
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<tr height="16">
<td style="font-size: 0px; line-height: 0;"
height="16"> </td>
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</div>
</div>
<div dir="auto" class="post typography"
style="font-size: 16px; line-height: 26px; padding:
16px 0 0 0;">
<div dir="auto" class="body markup"
style="font-size: 16px; line-height: 26px;
margin-bottom: 16px; text-align: initial; width:
100%; word-break: break-word;">
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;
margin-top: 0;">COVID-19 is not the common cold.
Here’s an effort to keep you up-to-date on long
COVID developments. </p>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Not “in the clear” after
first infection</h4>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>What we knew: </em><span>Long
COVID after </span><em>first </em><span>infection
was clearly a risk. The risk of long
COVID-19 after </span><em>re-infection</em><span>
was not known.</span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>New info: </em><a
href="https://substack.com/redirect/02b3097c-3bc8-430d-b747-8c940015c4ba?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">In the U.K.</a><span>,
risk of long COVID dropped after second
infections compared to first infection (4%
→ 2.4%). This is good and bad news: Risk
drops, but risk is clearly not zero. </span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>Why it matters: </em><span>There
is still reason to avoid COVID-19, even if
you’ve had it already. </span></p>
</li>
</ul>
<div class="captioned-image-container-static"
style="font-size: 16px; line-height: 26px;
margin: 32px auto;">
<figure style="margin: 0 auto; width: 100%;">
<table class="image-wrapper"
style="mso-padding-alt: 1em 0 1.6em;"
width="100%" cellspacing="0" cellpadding="0"
border="0">
<tbody>
<tr>
<td style="text-align: center;"><br>
</td>
<td class="content" style="text-align:
center;" width="566" align="left"><a
class="image-link" target="_blank"
href="https://substack.com/redirect/13b9c8f9-c3f0-41d0-80ee-7d8e038f3008?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="align-items: center;
border: none; display: block;
flex-direction: column; height:
auto; margin: 0; padding: 0;
position: relative; text-decoration:
none; width: auto;"
moz-do-not-send="true"><img
data-attrs="{"src":"https://substack-post-media.s3.amazonaws.com/public/images/74489f1f-3c99-474c-81a8-cedb6dfd51ec_1240x572.png","fullscreen":null,"imageSize":null,"height":572,"width":1240,"resizeWidth":566,"bytes":57502,"alt":null,"title":null,"type":"image/png","href":null,"belowTheFold":false,"internalRedirect":null}"
alt="" class="wide-image"
src="https://substackcdn.com/image/fetch/w_1132,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F74489f1f-3c99-474c-81a8-cedb6dfd51ec_1240x572.png"
style="-ms-interpolation-mode:
bicubic; border: none !important;
display: block; height: auto;
margin: 0 auto; margin-bottom: 0;
max-width: 100% !important;
vertical-align: middle; width:
auto !important;"
moz-do-not-send="true" width="550"
height="253.70967741935485"></a></td>
<td style="text-align: center;"><br>
</td>
</tr>
</tbody>
</table>
</figure>
</div>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Metformin may work</h4>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>What we knew: </em><span>~</span><a
href="https://substack.com/redirect/c23adf1b-8660-493f-894e-e24531062ef7?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">300 clinical trials</a><span>
are testing treatments for long COVID-19,
including Metformin. Results are trickling
in. </span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0 0 20px 0; margin-bottom: 0;
padding-left: 4px;"><em>New info:</em><span>
Metformin </span><a
href="https://substack.com/redirect/334e2d85-ee65-456c-9ac2-4ab0718d0da6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">reduced </a><span>long
COVID in a large randomized control trial.
</span></p>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height:
26px; margin: 0; margin-bottom: 0;
padding-left: 4px;">Metformin had a 42%
reduced risk in long COVID cases
compared to the placebo; 63% reduced
risk if taken within 4 days of symptoms.
</p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height:
26px; margin: 0; margin-bottom: 0;
padding-left: 4px;">For every 100 people
who took the drug, 4 fewer cases of long
COVID 9-months after infection occurred.
</p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height:
26px; margin: 0; margin-bottom: 0;
padding-left: 4px;">Ivermectin and
fluvoxamine had no impact. </p>
</li>
</ul>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>Why it matters: </em><span>People
should consider Metformin, especially
women who are at </span><a
href="https://substack.com/redirect/dc436b59-093d-432e-a014-7e62b38c13c6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">higher risk</a><span>
for long COVID. It’s best taken within 4
days of infection. This is a challenging
timeframe in the U.S. medical care system,
though. </span></p>
</li>
</ul>
<div class="captioned-image-container-static"
style="font-size: 16px; line-height: 26px;
margin: 32px auto;">
<figure style="margin: 0 auto; width: 100%;">
<table class="image-wrapper"
style="mso-padding-alt: 1em 0 1.6em;"
width="100%" cellspacing="0" cellpadding="0"
border="0">
<tbody>
<tr>
<td style="text-align: center;"><br>
</td>
<td class="content" style="text-align:
center;" width="572" align="left"><a
class="image-link" target="_blank"
href="https://substack.com/redirect/6282b384-2cfe-4542-baa7-324338c3910b?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="align-items: center;
border: none; display: block;
flex-direction: column; height:
auto; margin: 0; padding: 0;
position: relative; text-decoration:
none; width: auto;"
moz-do-not-send="true"><img
data-attrs="{"src":"https://substack-post-media.s3.amazonaws.com/public/images/2dc98f21-fbb8-43af-8f36-b2156328d821_1315x662.jpeg","fullscreen":null,"imageSize":null,"height":662,"width":1315,"resizeWidth":572,"bytes":384351,"alt":null,"title":null,"type":"image/jpeg","href":null,"belowTheFold":false,"internalRedirect":null}"
alt="" class="wide-image"
src="https://substackcdn.com/image/fetch/w_1144,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2dc98f21-fbb8-43af-8f36-b2156328d821_1315x662.jpeg"
style="-ms-interpolation-mode:
bicubic; border: none !important;
display: block; height: auto;
margin: 0 auto; margin-bottom: 0;
max-width: 100% !important;
vertical-align: middle; width:
auto !important;"
moz-do-not-send="true" width="550"
height="276.88212927756655"></a></td>
<td style="text-align: center;"><br>
</td>
</tr>
</tbody>
</table>
<figcaption class="image-caption"
style="box-sizing: content-box; color:
#808080; font-size: 14px; font-weight: 400;
letter-spacing: -0.15px; line-height: 20px;
margin-top: 8px; padding-left: 15%;
padding-right: 15%; text-align: center;
width: 70%;"><span>Cumulative incidence
curve of long COVID diagnoses over 10
months after randomization. Source: </span><a
href="https://substack.com/redirect/ab398a5c-dc59-47e9-b80a-fb1a1a04afdc?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="text-decoration: underline;"
moz-do-not-send="true">Lancet preprint</a><span>.</span></figcaption></figure>
</div>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Paxlovid may help… a
little? </h4>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>What we knew: </em><span>Paxlovid
helps reduce severe disease by </span><a
href="https://substack.com/redirect/f097f963-db21-4e4b-a24d-8cfb6f13b08d?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">50</a><span>-</span><a
href="https://substack.com/redirect/071d56c4-1a4c-4ba5-90d1-365ffedc7a68?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">90%</a><span>. We
didn’t know if it helped with long COVID,
though. </span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>New info:</em><span> Paxlovid
reduced risk of long COVID by </span><a
href="https://substack.com/redirect/55a17f35-b798-4009-972c-8beab70d90fb?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">26%</a><span>,
regardless of vaccination status and
history of prior infection. We need more
studies, particularly among young people,
as Paxlovid’s effect will likely </span><em>increase
</em><span>among younger people. </span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><em>Why it matters: </em><span>There
may be small, proxy benefits from taking
Paxlovid, including among younger
populations that aren’t “eligible.” </span></p>
</li>
</ul>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Long COVID is annoyingly
stubborn </h4>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>What
we didn’t know: </em><span>We didn’t know the
longevity of severe symptoms. </span></p>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>New
info: </em><span>Among those with long COVID,</span><em>
</em><span>the rate in which symptoms affected
daily life </span><a
href="https://substack.com/redirect/334e2d85-ee65-456c-9ac2-4ab0718d0da6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa; text-decoration:
none;" moz-do-not-send="true">decreased </a><span>from
45% → 25% over 7 months.</span></p>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>Why
it matters: </em><span>If you get severe long
COVID, there is a chance that symptoms will
get better after 7 months. Then again, there’s
a chance that they won’t. </span></p>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Still not convinced? </h4>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>What
we know: </em><span>People living with long
COVID report profound stigmatization because
people disbelieve that long COVID is a
“thing.”</span></p>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>New
info:</em><span> A YLE community member,
Dianna Cowarn (also known as Physics Babe on
YouTube), was diagnosed with long COVID last
summer. Her crew made a 4-min video. Check it
out here if you’re still not convinced. It’s
painstaking. </span></p>
<a
href="https://substack.com/redirect/d2df7479-23af-4cab-b76e-85332954f1b1?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
target="_blank" class="youtube-wrap"
style="display: block; margin: 1.6em 0;"
moz-do-not-send="true"><img
src="https://substackcdn.com/image/youtube/w_550,c_limit/l_youtube_play_qyqt8q,w_120/vydgkCCXbTA"
style="-ms-interpolation-mode: bicubic;
border: none !important; display: block;
height: auto; margin: 0 auto; max-width: 100%;
vertical-align: middle; width: 100%;"
moz-do-not-send="true"></a>
<h4 class="header-with-anchor-widget"
style="-moz-osx-font-smoothing:
subpixel-antialiased; -webkit-font-smoothing:
subpixel-antialiased; color: #404040;
font-family: 'SF Compact Display',
-apple-system, BlinkMacSystemFont, 'Segoe UI',
Roboto, Helvetica, Arial, sans-serif, 'Apple
Color Emoji', 'Segoe UI Emoji', 'Segoe UI
Symbol'; font-size: 1.125em; font-weight: bold;
line-height: 1.16em; margin: 1em 0 0.625em 0;
position: relative;">Bottom line</h4>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;">COVID-19
infection is not the common cold for some. Our
knowledge is inching closer to treatments. But
with so much unknown, we still need to emphasize
prevention—keeping COVID-19 cases low and
ensuring vaccination.</p>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;">Love,
YLE </p>
<div style="font-size: 16px; line-height: 26px;">
<hr style="background: #e0e0e0; border: none;
height: 1px; margin: 32px 0; padding: 0;"></div>
<p style="color: #404040; font-size: 16px;
line-height: 26px; margin: 0 0 20px 0;"><em>In
case you missed it: </em></p>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0; margin-bottom: 0; padding-left:
4px;"><span>The last </span><a
href="https://substack.com/redirect/86d3e601-ed40-46c9-a5c4-c5700e927aea?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">update </a><span>on
Long COVID</span></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height: 26px;
margin: 0 0 20px 0; margin-bottom: 0;
padding-left: 4px;">Long COVID mini-series:
</p>
<ul style="margin-top: 0; padding: 0;">
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height:
26px; margin: 0; margin-bottom: 0;
padding-left: 4px;"><a
href="https://substack.com/redirect/daa06a6e-ea92-4010-a3c5-43075923ea97?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo"
rel="" style="color: #538cfa;
text-decoration: none;"
moz-do-not-send="true">Burden</a></p>
</li>
<li style="margin: 8px 0 0 32px;
mso-special-format: bullet;">
<p style="box-sizing: border-box; color:
#404040; font-size: 16px; line-height:
26px; margin: 0; margin-bottom: 0;
padding-left: 4px;"><a
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<td style="width: 470px; padding-top: 12px; color:
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