[Hac-announce] Fwd: Catch up quick: Long COVID
Manny Sholem Ratafia
manny at ratafias.com
Tue Mar 14 12:49:25 EDT 2023
Some of you may be interested in this update on Long COVID from
epidemiologist Katelyn Jetelina. I thought I was following this topic
pretty well, but there's some new info here that was surprising to
me.--Manny
"Fight for the things that you care about, but do it
in a way that will lead others to join you."
― Ruth Bader Ginsburg
-------- Forwarded Message --------
Subject: Catch up quick: Long COVID
Date: Tue, 14 Mar 2023 16:16:26 +0000
From: Katelyn Jetelina from Your Local Epidemiologist
<yourlocalepidemiologist at substack.com>
Reply-To: Katelyn Jetelina from Your Local Epidemiologist
<reply+1rzqc6&a13t&&32b2ca6b5635e96470cad40341181835d29b5f2c82e9746ff82b488c42922e2f at mg1.substack.com>
To: manny at ratafias.com
Catch up quick: Long COVID
COVID-19 is not the common cold. Here’s an effort to keep you up-to-date
on long COVID developments. Not “in the clear” after first infection
What we knew: Long COVID after first infection was clearly a risk. The
risk of long COVID-19 after re-infection
Open in app
<https://open.substack.com/pub/yourlocalepidemiologist/p/catch-up-quick-long-covid?utm_source=email&redirect=app-store>
or online
<https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly95b3VybG9jYWxlcGlkZW1pb2xvZ2lzdC5zdWJzdGFjay5jb20vcC9jYXRjaC11cC1xdWljay1sb25nLWNvdmlkP3Rva2VuPWV5SjFjMlZ5WDJsa0lqbzBOamM1T1RNc0luQnZjM1JmYVdRaU9qRXdOelE0TWprd01pd2lhV0YwSWpveE5qYzRPREV3TmpBNExDSmxlSEFpT2pFMk9ERTBNREkyTURnc0ltbHpjeUk2SW5CMVlpMHlPREV5TVRraUxDSnpkV0lpT2lKd2IzTjBMWEpsWVdOMGFXOXVJbjAubHpIRi05bW5GM21BYUlObmhXeDJTUkNyNTR0c1BWX1gxdE1CV21teVYwWSIsInAiOjEwNzQ4MjkwMiwicyI6MjgxMjE5LCJmIjp0cnVlLCJ1Ijo0Njc5OTMsImlhdCI6MTY3ODgxMDYwOCwiZXhwIjoxNjgxNDAyNjA4LCJpc3MiOiJwdWItMCIsInN1YiI6ImxpbmstcmVkaXJlY3QifQ.s3DGz_Cd3PR4jYfL1w3L9uLAZP7DpMbgkeCNpDGct8Y?>
<https://substack.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.s3DGz_Cd3PR4jYfL1w3L9uLAZP7DpMbgkeCNpDGct8Y?>
/Si quiere leer la versión en español, pulse aquí
<https://substack.com/redirect/862304a6-192f-4bfb-99b7-2537368996b9?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>./
------------------------------------------------------------------------
Catch up quick: Long COVID
<https://substack.com/app-link/post?publication_id=281219&post_id=107482902&utm_source=post-email-title&isFreemail=true&token=eyJ1c2VyX2lkIjo0Njc5OTMsInBvc3RfaWQiOjEwNzQ4MjkwMiwiaWF0IjoxNjc4ODEwNjA4LCJleHAiOjE2ODE0MDI2MDgsImlzcyI6InB1Yi0yODEyMTkiLCJzdWIiOiJwb3N0LXJlYWN0aW9uIn0.lzHF-9mnF3mAaINnhWx2SRCr54tsPV_X1tMBWmmyV0Y>
Katelyn Jetelina
<https://substack.com/redirect/4df60a92-1a38-40fc-9d2b-703140fc9a50?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
Mar 14
<https://substack.com/redirect/4df60a92-1a38-40fc-9d2b-703140fc9a50?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
<https://substack.com/app-link/post?publication_id=281219&post_id=107482902&utm_source=substack&isFreemail=true&submitLike=true&token=eyJ1c2VyX2lkIjo0Njc5OTMsInBvc3RfaWQiOjEwNzQ4MjkwMiwicmVhY3Rpb24iOiLinaQiLCJpYXQiOjE2Nzg4MTA2MDgsImV4cCI6MTY4MTQwMjYwOCwiaXNzIjoicHViLTI4MTIxOSIsInN1YiI6InJlYWN0aW9uIn0.b4rVCjz1LWKdii0_FOgtTSLKOsujpFVDgGZmLLsSLgw&utm_medium=email>
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Save
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▷ Listen
<https://open.substack.com/pub/yourlocalepidemiologist/p/catch-up-quick-long-covid?utm_source=email-ufi&play_audio=true&token=eyJ1c2VyX2lkIjo0Njc5OTMsInBvc3RfaWQiOjEwNzQ4MjkwMiwiaWF0IjoxNjc4ODEwNjA4LCJleHAiOjE2ODE0MDI2MDgsImlzcyI6InB1Yi0yODEyMTkiLCJzdWIiOiJwb3N0LXJlYWN0aW9uIn0.lzHF-9mnF3mAaINnhWx2SRCr54tsPV_X1tMBWmmyV0Y>
COVID-19 is not the common cold. Here’s an effort to keep you up-to-date
on long COVID developments.
Not “in the clear” after first infection
*
/What we knew: /Long COVID after /first /infection was clearly a
risk. The risk of long COVID-19 after /re-infection/was not known.
*
/New info: /In the U.K.
<https://substack.com/redirect/02b3097c-3bc8-430d-b747-8c940015c4ba?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>,
risk of long COVID dropped after second infections compared to first
infection (4% → 2.4%). This is good and bad news: Risk drops, but
risk is clearly not zero.
*
/Why it matters: /There is still reason to avoid COVID-19, even if
you’ve had it already.
<https://substack.com/redirect/13b9c8f9-c3f0-41d0-80ee-7d8e038f3008?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
Metformin may work
*
/What we knew: /~300 clinical trials
<https://substack.com/redirect/c23adf1b-8660-493f-894e-e24531062ef7?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>are
testing treatments for long COVID-19, including Metformin. Results
are trickling in.
*
/New info:/Metformin reduced
<https://substack.com/redirect/334e2d85-ee65-456c-9ac2-4ab0718d0da6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>long
COVID in a large randomized control trial.
o
Metformin had a 42% reduced risk in long COVID cases compared to
the placebo; 63% reduced risk if taken within 4 days of symptoms.
o
For every 100 people who took the drug, 4 fewer cases of long
COVID 9-months after infection occurred.
o
Ivermectin and fluvoxamine had no impact.
*
/Why it matters: /People should consider Metformin, especially women
who are at higher risk
<https://substack.com/redirect/dc436b59-093d-432e-a014-7e62b38c13c6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>for
long COVID. It’s best taken within 4 days of infection. This is a
challenging timeframe in the U.S. medical care system, though.
<https://substack.com/redirect/6282b384-2cfe-4542-baa7-324338c3910b?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
Cumulative incidence curve of long COVID diagnoses over 10 months after
randomization. Source: Lancet preprint
<https://substack.com/redirect/ab398a5c-dc59-47e9-b80a-fb1a1a04afdc?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>.
Paxlovid may help… a little?
*
/What we knew: /Paxlovid helps reduce severe disease by 50
<https://substack.com/redirect/f097f963-db21-4e4b-a24d-8cfb6f13b08d?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>-90%
<https://substack.com/redirect/071d56c4-1a4c-4ba5-90d1-365ffedc7a68?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>.
We didn’t know if it helped with long COVID, though.
*
/New info:/Paxlovid reduced risk of long COVID by 26%
<https://substack.com/redirect/55a17f35-b798-4009-972c-8beab70d90fb?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>,
regardless of vaccination status and history of prior infection. We
need more studies, particularly among young people, as Paxlovid’s
effect will likely /increase /among younger people.
*
/Why it matters: /There may be small, proxy benefits from taking
Paxlovid, including among younger populations that aren’t “eligible.”
Long COVID is annoyingly stubborn
/What we didn’t know: /We didn’t know the longevity of severe symptoms.
/New info: /Among those with long COVID,//the rate in which symptoms
affected daily life decreased
<https://substack.com/redirect/334e2d85-ee65-456c-9ac2-4ab0718d0da6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>from
45% → 25% over 7 months.
/Why it matters: /If you get severe long COVID, there is a chance that
symptoms will get better after 7 months. Then again, there’s a chance
that they won’t.
Still not convinced?
/What we know: /People living with long COVID report profound
stigmatization because people disbelieve that long COVID is a “thing.”
/New info:/A YLE community member, Dianna Cowarn (also known as Physics
Babe on YouTube), was diagnosed with long COVID last summer. Her crew
made a 4-min video. Check it out here if you’re still not convinced.
It’s painstaking.
<https://substack.com/redirect/d2df7479-23af-4cab-b76e-85332954f1b1?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
Bottom line
COVID-19 infection is not the common cold for some. Our knowledge is
inching closer to treatments. But with so much unknown, we still need to
emphasize prevention—keeping COVID-19 cases low and ensuring vaccination.
Love, YLE
------------------------------------------------------------------------
/In case you missed it: /
*
The last update
<https://substack.com/redirect/86d3e601-ed40-46c9-a5c4-c5700e927aea?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>on
Long COVID
*
Long COVID mini-series:
o
Burden
<https://substack.com/redirect/daa06a6e-ea92-4010-a3c5-43075923ea97?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
o
The heart
<https://substack.com/redirect/8060d833-1184-4fea-9f20-fc0b8690745f?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
o
Kids
<https://substack.com/redirect/83c23736-d2e7-47f5-9874-907de11064e5?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
o
Predictors and treatment
<https://substack.com/redirect/dc436b59-093d-432e-a014-7e62b38c13c6?j=eyJ1IjoiYTEzdCJ9.fXnNfjqEHuJb90uhUC5MuKSqDSSONTVxMYyEVAne1uo>
------------------------------------------------------------------------
/“Your Local Epidemiologist (YLE)” is written by Dr. Katelyn Jetelina,
MPH PhD—an epidemiologist, data scientist, wife, and mom of two little
girls. During the day she works at a nonpartisan health policy think
tank and is a senior scientific consultant to a number of organizations,
including the CDC. At night she writes this newsletter. Her main goal is
to “translate” the ever-evolving public health science so that people
will be well equipped to make evidence-based decisions. This newsletter
is free thanks to the generous support of fellow YLE community members.
To support this effort, subscribe below:/
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